Axis 1: Resistance to viruses by loss of susceptibility

résistance virus

To successfully infect plants, viruses have to hijack host factors. Those can be turned into genetic resistances by making them unavailable to the pathogens.

We characterize plant susceptibility factors in plants and develop genetic resistances to viruses of agricultural importance.

  • by exploring the natural diversity of vegetable crops and wild related species and developing access to those wild species
  • by studying the interactions between plant and virus and deciphering resistance pathways mechanisms
  • by screening mutated populations or developing synthetic alleles using new biotechnological techniques

Relevant Publications

Kuroiwa, K., Thenault, C., Nogué, F., Perrot, L., Mazier, M. ,  Gallois, J.-L. (2022) CRISPR-based knock-out of eIF4E2 in a cherry tomato background successfully recapitulates resistance to pepper veinal mottle virus. Plant Science, Volume 316, [link]

Zafirov, D, Giovinazzo, N, Bastet, A, Gallois, J‐L. When a knockout is an Achilles’ heel: Resistance to one potyvirus species triggers hypersusceptibility to another one in Arabidopsis thaliana. Mol Plant Pathol. 2021; 22: 334– 347. [link]

Bastet A, Zafirov D, Giovinazzo N, Guyon-Debast A, Nogué F, Robaglia C, Gallois JL. Mimicking natural polymorphism in eIF4E by CRISPR-Cas9 base editing is associated with resistance to potyviruses. Plant Biotechnol J. 2019 Sep;17(9):1736-1750. doi: 10.1111/pbi.13096. [link]

Bastet, A., Robaglia, C. and Gallois, J.L. (2017) eIF4E Resistance: Natural Variation Should Guide Gene Editing. Trends Plant Sci, 22, 411-419. [link]

Boualem, A., Dogimont, C. and Bendahmane, A. (2016) The battle for survival between viruses and their host plants. Curr Opin Virol, 17, 32-38. [link]


JL Gallois (

Catherine Dogimont (

Modification date: 21 June 2023 | Publication date: 24 February 2022 | By: C. Lebaron